Forty patients with hyperpigmention after keloid, burn, skin graft, dermabrasion, and other surgical procedures were treated with a combination topical chemotherapy of vitamin A acid cream (0.1%), hydroquinone cream (5%) and triamcinolone acetonide cream (0.1%).
Among 21 patients who had been followed-up over 4 weeks, there was a objective improvement rate of 85.7% and a subjective improvement rate of 90.5%.
However, 19 cases who had been followed up under 4 weeks (drop out cases) were observed at the same period.
Topical combination chemotherapy may be another treatment method for the surgical patients with hyperpigmention which cannot be easily controlled by surgical procedures.
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